mosquito®

Our innovative mosquito positive displacement pipetting solutions combine the power of miniaturization and automation to reduce costs, improve productivity, and maximize research output. 

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High performance at a fraction of the cost

mosquito’s unique nanolitre liquid handling technology enables you to perform ‘traditional’ liquid handling tasks at a fraction of the volume, and at higher speeds. The instrument uses positive displacement, disposable micropipettes to handle low volumes of liquid in plate to plate, or intra plate transfers using contact dispensing. Each of mosquito’s disposable micropipettes has its own individual piston, not an air gap or system liquid, for true positive displacement pipetting.

 

mosquito in the lab

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"From a user experience, Mosquito LV is a reliable and robust machine. The precision and reproducibility delivered by the instruments is exceptional, a perfect fit for our single-cell protocols.

— Andres Gonzalez, Helmholtz Zentrum Munich

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"The mosquito is wonderful, very easy to use once it is set up and calibrated correctly. I've been using it to dispense small volumes into 384 well plates - so happy not to do it by hand!"

— Hayley Bennett, Genentech

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"The Mosquito transferred our ability to set up protein crystallization screens. The work of a day can be done in minutes."

— David Egan, Core Life Analytics

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When I came to BYU, I purchased a MosquitoXtal and my group and I have been very happy with its speed and accuracy. The MosquitoXtal allows us to set 96-288 drops in about 5 minutes, greatly reducing the man-hours needed to set trays. This is turn has accelerated our experimental pipeline immeasurably.

— Dr. James Moody, Department of Chemistry and Biochemistry, Brigham Young University

Find the right instrument for your application: 

Streamline drug discovery with miniaturized, automated workflows

mosquito systems help researchers to accelerate drug discovery and maximize research output by automating complex liquid handling tasks at low volumes. This reduces sample, reagent, and plastic waste, and increases assay robustness.
mosquito lv automated, high throughput liquid handler
mosquito® LV

Simplify low volume workflows in high throughput settings

mosquito LV  enables scientists to generate more experimental data from limited compound stocks. With transfer volumes as low as 25 nL and dead volumes below 0.3 μL, it supports assay miniaturization without compromising data quality, allowing more concentration-response curves, replicate plates and reaction conditions to be explored from every sample. Whether screening large libraries or evaluating newly synthesized compounds, mosquito LV extends the reach of valuable material. 

mosquito hv Powerful and precise liquid handler
mosquito® HV

Powerful and precise liquid handling performance

mosquito HV  bridges the gap between compound stocks and screening-ready assays. It streamlines source plate preparation for acoustic liquid handling, dilution series generation and assay setup, providing a reliable route from compound management to downstream screening and profiling studies. Consistent transfers across aqueous and DMSO-based solutions simplify workflow setup and support reproducible experimental outcomes. 

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mosquito® X1

High speed, low volume hit picking

mosquito X1 removes bottlenecks between compound selection and follow-up studies. With rapid cherry-picking in as little as 6 seconds per compound, it simplifies hit confirmation, sample normalization and plate reformatting, enabling compounds to be progressed efficiently into secondary screening, profiling and characterization workflows. Rapid access to selected samples supports timely decisions during hit expansion and lead optimization. 

Realize the benefits of the genomics revolution

As Next Generation Sequencing (NGS) costs have reduced, sample numbers have dramatically increased leading to a sample and library preparation bottleneck. Harnessing automation and miniaturization enables researchers to realize the full benefits of the genomics revolution. Our solutions dramatically improve productivity and reduce cost per sample for applications such as PCR, quantification and normalization, synthetic biology and a range of NGS library preparation methods supporting single cell genomics, transcriptomics, microbiome and metagenomics, agbio, clinical genomics and pathogen surveillance. 
mosquito gen3 multi-channel pipetting for genomics liquid handling
mosquito® Gen3

Our most compact and accessible automated low-volume liquid handler

Introducing our most compact and accessible member of the mosquito family. mosquito Gen3 offers highly accurate and precise multi-channel pipetting from 500 nL to 5 µL, allowing genomics researchers to benefit from miniaturization across a range of applications, irrespective of liquid class. The instrument’s rapid plate-to-plate pipetting motion and tip exchange maximize speed and efficiency.

mosquito hv genomics liquid handler for miniaturized workflows
mosquito® HV genomics

Unlocking the potential of genomics with miniaturized liquid handling

For those looking for higher throughput and greater walkaway capacity, mosquito HV genomics delivers the same highly accurate and precise multi-channel pipetting but with two additional deck positions. Run full miniaturized workflows with less hands-on time, and have confidence handling even the most viscous and volatile liquids from 500 nL to 5 µL.

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mosquito® LV Genomics

Accurate and precise multi-channel positive displacement pipetting

If you're looking to work with even smaller volumes, then mosquito LV genomics is for you. This instrument delivers exceptionally accurate and precise multi-channel pipetting from 25 nL to 1.2 μL, enabling you to extend the reach of precious samples and reagents even further.

Automate protein crystallization screening

Automated systems for protein crystallization screening are unlocking the potential of crystallography-based structural biology to allow rapid, reliable, and reproducible crystallization screen transfers. 
mosquito xtal3 Rapid and efficient protein crystal screening
mosquito® xtal3

Rapid and efficient protein crystal screening

mosquito Xtal3 combines speed, accuracy and performance in crystallization drop set up. The instrument enables researchers to use smaller volumes of precious protein samples without risk of contamination and automate popular protein crystallization screening techniques to accelerate research. 

mosquito LCP Accurate, reproducible automation for liquid cubic phase (LCP) setups
mosquito® LCP

Accurate, reproducible automation for liquid cubic phase (LCP) setups

mosquito LCP for membrane protein crystallization enables accurate, reproducible automation for liquid cubic phase (LCP) set-ups. The innovative positive displacement technology overcomes the common problems encountered with accurately dispensing the highly viscous LCP materials. Automated calibration of syringe and pipette positioning ensures precise drop-on-drop placement for easy automated imaging. 

mosquito crystal Fast, accurate, and precise pipetting for protein crystallography
mosquito® LV crystal

Fast, accurate, and precise pipetting for protein crystallography

The mosquito crystal combines speed, accuracy, and high precision pipetting of nanolitre volumes with zero cross-contamination from a disposable tip. Volumes as low as 10 nL on multi-aspirate allow researchers to make the most of precious protein samples while benefiting from the adaptability to easily change methods. 

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Expand the performance of your mosquito

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Software that's intuitive by design

The liquid handling software that controls the mosquito family of instruments gives users an intuitive experience tailored to their application area.

Developed in collaboration with scientists, the latest mosquito software facilitates miniaturization in novel application areas. Packed with powerful features, the software includes an experiment designer and helpful wizards to create and manage your protocols.

Learn more about the mosquito software

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Accessories

We have a range of accessories available for our mosquito range. Our accessories include a cooling block, humidity chamber, LCP mixer, and more. Each accessory is designed to expand the performance of your mosquito.

Explore mosquito accessories

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Consumables

Order your mosquito spools and other consumables using our online store.

Order mosquito consumables

Kamilla video of mosquito HV genomics

10 mins

mosquito HV genomics - NGS library preparation workflow
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Paul Thaw mosquito Xtal3 overview video image

5 mins

mosquito Xtal3 - Instrument overview
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mosquito lcp overview

7 mins

mosquito LCP - Instrument overview
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