Rapid and efficient protein crystal screening

mosquito Xtal3 combines speed, accuracy and performance in crystallization drop set up. The instrument enables researchers to use smaller volumes of precious protein samples without risk of contamination and automate popular protein crystallization screening techniques to accelerate research.
Walk up and use technology
Walk up and use technology
Even novice users master the use of the mosquito Xtal3 quickly, minimizing set up time and increasing productivity. The intuitive touch screen application-driven software and quick and easy experimental guides for rapid set-up streamline the overall user experience.
Faster and more efficient screening of crystallization space
Faster and more efficient screening of crystallization space
The instrument enables exceptionally fast and accurate drop setup across a wide viscosity range, dramatically increasing efficiency compared with traditional methods.
Access volumes as low as 10 nL
Access volumes as low as 10 nL

mosquito Xtal3 enables researchers to use smaller volumes of protein sample, and reduce screen consumption to realize cost savings when using valuable compounds as additives.

True positive displacement pipetting delivers exceptional accuracy
True positive displacement pipetting delivers exceptional accuracy
Harnessing innovative positive displacement pipetting, mosquito Xtal3 uses disposable micropipettes with individual pistons to deliver exceptional accuracy and precision, irrespective of liquid class.
Enables experimental flexibility
Enables experimental flexibility

The instrument enables experimental flexibility by automating commonly used protein crystallization screening techniques including hanging drop, sitting drop and microbatch as well as seeding or additive screening plate preparation.

Track record of reliability
Track record of reliability

Robust day-to-day performance with no blocking or clogging maximizes uptime, and safeguards research outcomes.

We’re revolutionizing liquid handling

Our liquid handling portfolio provides you with accurate and repeatable nanolitre to microlitre pipetting, every time, irrespective of liquid viscosity or environmental conditions.

High performance technology

Our liquid handling instruments harness innovative technology to streamline workflows and accelerate research.

Robust, reliable, and easy to use, our products overcome tough technical challenges and enable researchers to focus on the best science.

True positive displacement pipetting

Each of our disposable micropipettes has its own individual piston, not an air gap or system liquid, offering true positive displacement pipetting with no risk of cross-contamination.

Precise humidity control at your fingertips with up to a 90% reduction in drop evaporation

Sample evaporation can be a problem when dispensing very low volumes or volatile samples, causing inconsistent drop volumes, especially when environmental conditions and local humidity vary. mosquito’s precise humidity chamber reduces experimental inconsistencies by allowing users to robustly control the relative humidity of each experiment.

Intuitive by design

Our application led software for protein crystallography combines usability and functionality, with an intuitive user experience tailored to each scientific application. Through collaboration with scientists, our software team develops and enhances the instrument UI to provide the optimal user experience and facilitate adoption into novel application areas.

Enhance protein crystallization research capabilities

Additional components such as a humidity chamber and spool cover enhance protein crystallization screening capabilities.

Rapid, reliable, and reproducible crystallization screen transfers

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mosquito Xtal3 Citations

Technical Specification

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Pipetting range 25 nL - 1.2 µL Throughput 2 minutes/ 96-well plate
Primary SBS plate format 48 and 96 Accessories Precise humidity chamber and spool cover
Weight 27 kg (59 lbs) Dimensions (W x D x H) 545 mm x 470 mm x 690 mm
21.4 in x 18.5 in x 27 in
Technical variants 3 plate position deck


Order your mosquito Xtal3 spools and other consumables using our online store.

Order mosquito Xtal3 consumables