Accurate, reproducible automation for liquid cubic phase (LCP) setups

mosquito LCP for membrane protein crystallization enables accurate, reproducible automation for liquid cubic phase (LCP) setups.

The innovative positive displacement technology overcomes the common problems encountered with accurately dispensing the highly viscous LCP materials. Automated calibration of syringe and pipette positioning ensures precise drop-on-drop placement for easy automated imaging.

mosquito LCP includes all the functionality of mosquito crystal for automated vapor diffusion setups, allowing researchers to set up both LCP and traditional protein crystallization experiments in any commercially available plate, using a single instrument.

Dispense lipidic cubic phase (LCP) volumes as low as 25 nL
Dispense lipidic cubic phase (LCP) volumes as low as 25 nL
mosquito LCP unlocks the benefits of miniaturization, enabling researchers to use smaller volumes of protein sample and reduce screen consumption to realize substantial cost savings.
Walk up and use technology
Walk up and use technology
Even novice users master the use of the mosquito LCP quickly, minimizing setup time and increasing productivity. The intuitive touch screen application-driven software and quick and easy experimental guides for rapid setup streamline the overall user experience.
True positive displacement pipetting delivers exceptional accuracy
True positive displacement pipetting delivers exceptional accuracy

mosquito LCP harnesses innovative positive displacement pipetting by using disposable micropipettes with individual pistons to deliver exceptional accuracy and precision, irrespective of liquid class.

Track record of reliability
Track record of reliability
Robust day-to-day performance with no blocking or clogging maximizes uptime, and safeguards research outcomes.
Simplify set up of crystallization methods
Simplify set up of crystallization methods

Benefit from the ability to set up both LCP and all traditional protein crystallization experiments with a single instrument using commercially available SBS format plates.

Precise humidity control improves consistency
Precise humidity control improves consistency

mosquito’s active humidity chamber increases quality by reducing experimental inconsistencies caused by variation in environmental humidity.

We’re revolutionizing liquid handling

Our liquid handling portfolio provides you with accurate and repeatable nanolitre to microlitre pipetting, every time, irrespective of liquid viscosity or environmental conditions.

High performance technology

Our liquid handling instruments harness innovative technology to streamline workflows and accelerate research.

Robust, reliable, and easy to use, our products overcome tough technical challenges and enable researchers to focus on the best science.

True positive displacement pipetting 

Each of our disposable micropipettes has its own individual piston, not an air gap or system liquid, offering true positive displacement pipetting with no risk of cross-contamination.

Precise humidity control at your fingertips with up to a 90% reduction in drop evaporation

Sample evaporation can be a problem when dispensing very low volumes or volatile samples, causing inconsistent drop volumes, especially when environmental conditions and local humidity vary. mosquito’s precise humidity chamber reduces experimental inconsistencies by allowing users to robustly control the relative humidity of each experimen

Intuitive by design

Our application led software for protein crystallography combines usability and functionality, with an intuitive user experience tailored to each scientific application. Through collaboration with scientists, our software team develops and enhances the instrument UI to provide the optimal user experience and facilitate adoption into novel application areas.

Enhance protein crystallization research capabilities

Additional components such as a humidity chamber and an automated mixer for preparing LCP enhance the instrument’s capabilities. mosquito integrates seamlessly with a wide variety of laboratory instrumentation, including robotic plate handlers, stackers and bulk liquid handlers.

Technical Specification

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Pipetting range 25 nL - 1.2 µL Throughput 2 minutes/ standard 96-well plate
4 minutes/ 96-well LCP plate
Primary SBS plate formats 48, 96 and 384 Accessories Active humidity chamber, spool cover and LCP mixer
Weight 34 kg (75 lbs) Dimensions (W x D x H) 440 mm (790 mm 4 plate deck) x 470 mm x 690 mm
17.3 in (31 in 4 plate deck) x 18.5 in x 27 in
Technical variants 2 or 4 plate position deck

What our customers say about mosquito LCP

The mosquito LCP is our workhorse instrument for the accurate and reliable dispensing of sub-microliter droplet from aqueous and LCP solutions. Reproducibility is key to what we do and the mosquito certainly delivers with excellent speed.

Service support is critical to ensuring maximum use of the instrument and the team at SPT Labtech is extremely flexible and deliver to our high expectations.

Paul McEwan

Evotec (UK) Ltd.

Great to use and great results.

Easy to use and saves a lot of time, very efficient use of sample. Easy maintenance.

Chitra Rajendran

University of Regensburg

An ESSENTIAL piece of the structure determination pipeline for membrane proteins!

The mosquito-LCP is an absolutely ESSENTIAL piece of equipment in modern crystallography and even more so if working on membrane proteins and wish to pursue lipidic cubic phase (LCP) crystallization!!! The software is intuitive and customizable to accommodate many different types of crystallization methods including under oil, sitting/hanging drop vaporization and LCP. The mosquito-LCP does everything the mosquito-Crystal can do and more! With the LCP module, you can now quickly and efficiently set up sandwich trays of your favorite membrane protein using the wildly successful LCP method. And with the humidification chamber (a must have!), you never have to worry about your drops drying out! Disposable tips eliminate the possibility of cross-contamination and the 8-tip pipette head ensures fast and accurate drops every time. The mosquito-LCP truly is an ESSENTIAL piece of the membrane protein structure determination pipeline!

Nicholas Noinaj

Purdue University - Biological Sciences - Structural Biology - Purdue Institute of Inflammation, Imm

Purchasing the Mosquito LCP was the best thing our lab could have done, as it's allowed us to move our science forward faster and at a lower cost.

We have used our Mosquito LCP since 2011, and like other TTP Labtech instruments in our lab, it has been robust and easy to use. In the time we've had our Mosquito, our researchers have set up thousands of experiments with it at a fraction of the cost and time that it would have taken using manual methods. Purchasing the Mosquito LCP was the best thing our lab could have done, as it's allowed us to move our science forward faster and at a lower cost than we could have ever achieved without it. Training and use of the Mosquito LCP is easy, and the service we have received from TTP has been top-notch from the start. We couldn't ask for more from our Mosquito LCP or TTP.

Chris Waddling

UC San Francisco