Structural
Biology

The dynamic field of structural biology investigates the molecular structure of biological macromolecules to understand fundamental life processes and tackle disease.

New techniques are revolutionizing structural biology

New technological advances and techniques in Cryo-EM and protein crystallography have inspired a structural biology revolution, enabling researchers to tackle even more complex biological problems to benefit scientific research. ‘Integrative’ structural biology brings together multiple approaches to build a more comprehensive picture of dynamic processes at both a cellular and molecular level.

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Transmission electron
microscopy

Transmission electron microscopy is a promising and adaptable technique providing researchers with valuable insights on intricate biological structures ranging from individual biomolecules to whole cells.

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Cryo-Electron
Microscopy (Cryo-EM)

Cryo-EM has ushered in a new era of scientific discovery with the production of increasingly higher-resolution structural information.  Advances in hardware and software have now opened up the technique to more widespread adoption in basic research and drug discovery.

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Single Particle
Analysis

Single particle analysis (SPA) is a well-established cryo-electron microscopy technique, allowing structural biologists to investigate the detailed structures of macromolecules at near-atomic resolution to uncover rich biological insights.

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Cryo-Tomography

Cryo-electron tomography (cryo-ET) uses 3D molecular-level imaging to produce high-resolution structural and spatial information about individual proteins and the cellular environment where they operate.

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Micro Electron Diffraction

Micro electron diffraction (MicroED) is a developing technique for determining the structure of proteins from nanocrystals bringing together cryo-EM sample preparation approaches with electron and X-ray crystallography data analytics.

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Protein crystallography

The automation of protein crystallography screening has made a significant contribution to the rapid expansion of crystallography-based structural biology. Obtaining crystals of a high enough resolution for X-ray diffraction studies can be time and cost intensive, requiring an extensive number of screening and optimization experiments to determine ideal conditions for crystal growth.

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Protein crystallography methods

Protein crystallography encompasses a range of techniques such as vapor diffusion and batch crystallization methods to deliver protein structure data in dynamic research environments. Agile solutions are needed to allow researchers to adapt approaches between multiple projects.

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Crystal screen
optimization

Optimizing protein crystallization hits to improve diffraction can be onerous.  Automating the preparation of complex gradients from stock solutions saves time, improves repeatability, and increases the output of high resolution structures.

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Check out the latest publication references for our structural biology instruments.
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Meet our Field Application Scientists

Our Field Application Scientists will help you to advance your research goals throughout the life of your instrument, optimizing for the applications you need and harnessing its full potential. As specialists in a range of disciplines including structural biology, the team ensures that the protocols for your applications are scientifically robust, giving you the confidence to pursue novel approaches. Working closely with customers, Field Application Scientists eliminate bottlenecks and streamline workflows to enable successful research outcomes.

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Find out more about our team
We make instruments that change the way scientists work.

As a team of exceptionally skilled scientists, engineers and business innovators, we have one mission: to work together to accelerate life science research.

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