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Fast, accurate, and precise pipetting for protein crystallography

The original mosquito crystal combines speed, accuracy, and high precision pipetting of nanolitre volumes with zero cross-contamination from a disposable tip. Volumes as low as 10 nL on multi-aspirate allow researchers to make the most of precious protein samples while benefiting from the adaptability to easily change methods to accommodate individual projects.

Enabling experimental flexibility
Enabling experimental flexibility

By automating commonly used protein crystallization screening techniques including hanging drop, sitting drop and microbatch as well as seeding or additive screening plate preparation the instrument enables experimental flexibility. The instrument also offers researchers the flexibility setup all traditional (non-LCP) protein crystallization experiments as well as enabling some other screening methods such as serial dilution work.

Walk up and use technology
Walk up and use technology

Even novice users master use of the mosquito crystal quickly, minimizing set up time and increasing productivity. The intuitive touch screen application-driven software and quick and easy experimental guides for rapid setup streamline the overall user experience.

Designed for seamless workflow integration
Designed for seamless workflow integration

mosquito crystal integrates seamlessly with a wide variety of laboratory instrumentation, including robotic plate handlers, stackers and bulk liquid handlers to achieve walk-away operation in many application areas.

Access volumes as low as 10 nL on multi-aspirate
Access volumes as low as 10 nL on multi-aspirate

mosquito crystal enables researchers to use smaller volumes of protein sample and reduce screen consumption to realize substantial cost savings.

True positive displacement pipetting delivers exceptional accuracy
True positive displacement pipetting delivers exceptional accuracy

The instrument harnesses innovative positive displacement pipetting by using disposable micropipettes with individual pistons to deliver exceptional accuracy and precision, irrespective of liquid class.

Track record of reliability
Track record of reliability

Robust day-to-day performance with no blocking or clogging maximizes uptime, and safeguards research outcomes.

We’re revolutionising liquid handling

Our liquid handling portfolio provides you with accurate and repeatable nanolitre to microlitre pipetting, every time, irrespective of liquid viscosity or environmental conditions.

High performance technology

Our liquid handling instruments harness innovative technology to streamline workflows and accelerate research.

Robust, reliable, and easy to use, our products overcome tough technical challenges and enable researchers to focus on the best science. 

True positive displacement pipetting 

Each of our disposable micropipettes has its own individual piston, not an air gap or system liquid, offering true positive displacement pipetting with no risk of cross-contamination.

Humidity control at your fingertips with up to a 90% reduction in drop evaporation

Sample evaporation can be a problem when dispensing very low volumes or volatile samples, causing inconsistent drop volumes, especially when environmental conditions and local humidity vary. mosquito’s active humidity chamber reduces experimental inconsistencies by allowing users to robustly control the relative humidity of each experiment.

Intuitive by design

Our application led software for protein crystallography combines usability and functionality, with an intuitive user experience tailored to each scientific application. Through collaboration with scientists, our software team develops and enhances the instrument UI to provide the optimal user experience and facilitate adoption into novel application areas.

Enhance protein crystallization research capabilities

Additional components such as a humidity chamber and spool cover enhance protein crystallization screening capabilities.

Technical Specification

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Pipetting range 25 nL - 1.2 µL Throughput 2 minutes/ 96-well plate
Primary SBS plate formats 48, 96 and 384 Accessories Active humidity chamber and spool cover
Weight 27 kg (59 lbs) Dimensions (W x D x H) 390 mm (790 mm 5 plate deck) x 470 mm x 690 mm
15.5 in (31 in 5 plate deck) x 18.5 in x 27 in
Technical variants 2 or 5 plate position deck

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What our customers say about mosquito crystal

The mosquito is a wonderful addition to our University. It can do in less than 5 minutes what takes me to do in more than 8 hours. The nanoliter liquid handling capabilities produce drop size and placement speed that are not humanly possible.

James Caldwell

San Diego State University

Longest lasting robot without major downtime.

After testing several robots from different companies, we recently decided to buy a second instrument, since the first one was our main work horse and the favorite of all users. There is no maintenance to be done after using it which is an advantage in an Open Access lab. It is easy to calibrate and to adjust according to the wishes of the users.

Gabriele Rummel

Novartis AG

10x faster then manual for protein crystallization.

The Mosquito transferred our ability to set up protein crystallization screens. The work of a day can be done in minutes,

David Egan

Core Life Analytics

An excellent piece of equipment for crystallography!

The robot is very easy to use with very little room for mistakes. The liquid pipetted from the tips are well placed in the well and consistent in position and volume. The interface is easy to understand in a user-friendly environment; the simulation mode allows for validations and safety measures before carrying out any experiments. The robot has the ability to dispense liquid to a myriad of different plate types which gives way to unlimited options. Cares are quite easy, only need to replace the tips spool once it runs out which takes no time at all. The rooms for attachment i.e., LCP crystallography and humidifier adds a lot more varieties to accommodate different goals. All those combined would make the robot well worth the money.

Adli Aziz

University of Sheffield