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apricot S3 Pipettor - Accessible Automation & Endless Research Possibilities
Recently, we introduced our apricot range of user-friendly liquid handling instruments to the SPT Labtech business. The apricot S3 pipettor is one of the core products in the range, offering automated high-performance 96 and 384 channel pipetting...
Sample Prep Series Part 4: Towards Routine Sample Specific Optimization for All
As cryo-EM adoption has grown so has the demand to prepare specimen using conventional commercial instruments and DIY set ups. However, most samples exhibit non-ideal behavior and the resulting specimen rarely achieve the reproducible and...
Sample Prep Series Part 1: Preparing your sample for vitrification
Sample preservation in vitrified ice (vitrification) is widely acknowledged as the first step in the cryogenic electron microscopy (Cryo-EM) workflow. However, prior to sample preparation researchers must consider the sample quality and determine...
Sample Prep Series Part 3: Next Generation Sample Preparation
The period responsible for the current generation of cryogenic electron microscopy (cryo-EM) instrumentation and image processing software is often referred to as the “resolution revolution.” The results of these technological advancements have...
Sample Prep Series Part 2: Conventional Plunge Vitrification Optimization
The preparation of acceptable frozen-hydrated samples on transmission electron microscopy (TEM) grids is well known to be a challenging bottleneck in the cryogenic electron microscopy (cryo-EM) workflow. During sample vitrification it is assumed...
Is your assay really optimized?
In response to the question “Is your assay really optimized?” the answer we hear the most is – “It’s good enough” So, if your process isn’t broken, why on earth would you consider fixing it?
Why hasn’t DoE been readily adopted within Life Sciences?
So, is Design of Experiments (DoE), just a passing trend? DoE might appear to be a relatively new buzz word or concept, but rest assured it’s worth has been proven long ago within other industries. Why therefore hasn’t the approach been readily...
Why you should care how assays are developed?
Thanks to high throughput automation, delivering large scale library screens is very much a matter of routine but bottlenecks have an annoying habit of shifting. Has the pressure to keep pace now shifted upstream to your assay development and...
Biobanks, could you be unwittingly degrading your samples?
Avoiding sample degradation is essential to ensure the integrity of the research efforts that biobanks support. A constant freezer temperature is a crucial factor in ensuring sample quality since a warm storage environment, even for a short...
How structural biology is playing a role in tackling the COVID-19 pandemic
The recent COVID-19 global pandemic has unleashed a massive global response to develop therapeutic treatments for those suffering from COVID-19 and a vaccine against the SARS-CoV-2 virus. Structural biologists from all over the world have...
How could a coordinated ecosystem of specialist biobanks improve global research?
Biobanks have become an essential cornerstone of medical research - enabling drug discovery and development, supporting biomarker research and deepening our understanding of disease mechanisms. As we advance towards an era of personalized...
Sample integrity versus storage temperature. What can we learn from penguins?
A new report from the National Academies of Sciences, Engineering and Medicine addresses concerns about reproducibility and replicability in scientific research. Sitting near the top of the “food chain”, it is imperative that sample management...