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The perfect couple for GPCR
Obtaining detailed structures of any membrane protein has been challenging. A detergent is required to extract the protein from the lipid environment which does not contribute to a favorable environment for crystallization using traditional vapor...
When not binding to a target’s binding site is better!
Most drugs bind to a target’s binding site (orthosteric binding). However, binding to a site distant from the binding site appears to have some very significant advantages over orthosteric binding, one of which is reducing off-target side-effects.
Membrane protein crystallography – is it still a fine art?
Membrane proteins serve a number of vital roles in the body, including oxygen production, transport of nutrients into cells, transport of water into and out of cells, removal of waste products, and allowing information to enter cells. Thirty percent...
The world’s first pig biobank
A recent edition of Nature discusses a repository at Munich’s Ludwig Maximilian University (LMU), Germany of pig samples from a genetically engineered pig model of diabetes (Abbott, A. (2015)Nature519: 397-8). Samples from Boar 1339 were divided...