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Optimize cryo-EM sample preparation workflows
chameleon delivers optimized grid vitrification for cryo-EM by combining next-generation automation, blotless grid technology, and high speed plunging. Thinking beyond existing sample preparation workflows enables routine high resolution structural studies.
Onboard cameras provide visual images during freezing
Enabling the easier selection of only good grids based on visual images during freezing reduces the requirement for costly microscope screening and saves valuable research time.
High-speed plunging
chameleon’s high speed plunging capability reduces air-water interface protein denaturation effects and allows better handling of difficult samples to improve quality and enable better research outcomes.
Blot-free technology
The blot-free technology using self wicking grids minimizes variability and enables researchers to gain precise sample specific control of ice thickness.
Precise automated grid handling
With almost no manual handling required, chameleon eliminates common grid damage and loss issues to increase workflow efficiency and reduce waste.
Guided workflows enable simple set up, use and cleaning
Intuitive design makes the instrument easy to use even for novice operators, minimizing training time and streamlining set up.
In-line glow discharge
Easily apply real time adjustments to perfect your sample behaviour and achieve the perfect ice thickness.
Automated cryogen level sensing and temperature control
Ensure the safe storage and control of cryogens in an automated drawer to maintain their stability and quality and assure research integrity.
Captures all relevant grid parameters and images
Improved data collection and record keeping enables future repeatability as well as data mining to inform new research avenues.
How to access chameleon
If you have a cryo-EM sample that you would like to prepare using chameleon’s optimized grid vitrification, you can access the instrument directly at various sites or via more widespread, free-to-access programs.
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The chameleon has enabled an efficient cryoEM workflow for Arvinas by allowing us to freeze our samples promptly upon elution from the column, thus allowing rapid capture of complexes on grids ready for cryoEM data collection. By improving sample quality and reducing screening loads on microscopes, chameleon has allowed us to leverage both academic and industry partners for data collection. This allows us to focus our resources and efforts on producing high-quality protein complexes to advance the field of PROTAC® protein degradation.
Katie Digianantonio, PhD
Research Investigator
