Crystallizing membrane proteins in Lipidic Cubic Phase (in-meso)

The Lipidic Cubic Phase (LCP) or in-meso technique for crystallizing membrane proteins has revolutionized structural studies of difficult targets such as GPCRs.

LCP drop

LCP (in-meso)

In Lipidic Cubic Phase (LCP), mosquito® LCP provides the combination of four important factors:

  • reduction of sample size down to nanolitre volumes
  • speed (about 4 minutes to complete a single 96-well LCP plate)
  • accuracy and repeatability
  • humidity control of the dispensing environment

LCP dispensing drops

Low volume dispensing

mosquito LCP allows you to dispense Lipidic Cubic Phase (LCP) volumes as low as 25 nL, while automated calibration of syringe and pipette positioning ensures precise drop-on-drop placement.

Read what protein crystallographers say about our products and services

Diamond Light Source, Oxford, UK

We really need a crystallization machine that is easy to work with and reliable.....that’s our mosquito!

Dr. Isabel Moraes, MPL coordinator and group leader

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European Molecular Biology Laboratory, Hamburg, Germany

The acquisition of the mosquito-LCP contributed significantly to the quality of our services. EMBL’s decision to integrate SPT Labtech equipments underlines their outstanding performance - a driving force in the progress of science.

Dr. Stephane Boivin, Staff Scientist

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Heptares Therapeutics Ltd.

mosquito LCP provided a reliable platform for our CRF1 LCP crystallization, deploying reproducible low volume boli at speed, and ultimately yielding a large sample set of CRF1 crystals for subsequent diffraction analysis.

Dr. Andrew S. Doré, Head of Crystallography

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iQ plate


Essentials for innovative technology
active humidity chamber


Liquid handling essentials for enhanced membrane protein crystallization
Lab image

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