Liquid handling for sitting drop creation
Fast and repeatable sitting drop crystallization, combining experimental flexibility with perfect drop placement.
Standard vapor diffusion
Using mosquito crystal® for setting up vapor diffusion techniques has distinct advantages in multiple user research laboratories and academic groups, as both set-ups are easily automated without the need for changes in instrument configuration.
Microbatch screen set-up
The multi-aspirate, dispense and drop mixing capabilities of mosquito crystal are perfect for
Microseeding
Seeding or micro matrix seeding (MMS) is a well-established method used to improve the quality and reproducibility of protein crystals. mosquito's plate set-up time is less than 3 minutes to create multiple aspirations before pipetting to ensure that no protein or seed stock is wasted.
Additive screening
mosquito's unique true positive displacement pipettes combined with its multi-aspirate function allows users to access volumes down to 10 nL. Not only does this save on precious ligands/compounds,
Crystal soaking
Soaking protein crystals with ligands is the fastest route to produce high-throughput structures for
Bicelles
By maintaining a cold environment and pre-chilling the sample holder block it is possible to use mosquito crystal to accurately and easily pipette the bicelle solution, thereby facilitating the automation of screening for this lipidic based technique of membrane protein crystallization.
Read what protein crystallographers say about our products and services
Excellent liquid handling for setting up sitting drop crystallography experiments. It was fast! We set up over 4000 experiments with 8 proteins in only 6 hours. I had 27 ‘hits’ for crystallography conditions out of 480 mother liquor conditions.
Dr. James Caldwell, Postdoctoral Research Fellow
In our lab, the mosquito crystal is invaluable for crystallography, but is also used outside crystallography where small volume liquid handling is required.
Dr. David Hargreaves, Associate Principal Scientist
The mosquito instrument is the iPad of robotic. In a few words, it is really easy to use and program, fast to perform tasks and don't require a lot of maintenance (robust). It's the perfect instrument for doing high throughput screening of crystallization conditions. It will perfectly integrate in lab environment since it just requires a bench and a power point.
Dr. Guillaume Gotthard, Postdoctoral Researcher
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