Resources

Explore insightful resources that include videos, whitepapers, eBooks, application notes and more

The Future Is Here: Precision Automation Demonstrates Its Value as a Tool for Accelerating Drug Discovery

With more than 70 FDA-approved small molecules ,kinase inhibition continues to attract significant investment. Identification and characterization of novel inhibitors is a challenging, yet critical task which sets the tone for future successes and failures. Traditional single shot approaches do not meet current requirements for machine learning and carry significant risks of false negatives. Hit profiling has evolved this concept, generating potency estimates, reducing risks while providing contextual confidence. Accurate hit identification followed by high resolution, kinetic molecular profiling enhances outcomes ensuring better data-driven decision-making earlier in the process, saving time and resources, leading to superior molecular design.

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Poster
SLAS 2023 Interview - Chris Waddling - dynamic duo

Discover how genomics researchers can miniaturize NGS methods to increase throughput and lower costs using the combination of the mosquito® and dragonfly® automated liquid handlers from SPT Labtech in this interview with Field Application Scientist, Chris Waddling.

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Video
encapsulated nanodroplet crystallisation (ENaCt) for small organic molecules: polymorph discovery

Crystallisation is of vital importance to the drug development pipeline of the pharmaceutical industry due to the existence of multiple crystal forms (e.g. cocrystals, solvates and polymorphs) of an active pharmaceutical ingredient (API). The physical properties of the crystal form of an API are important in manufacturing, API stability and can have significant impact on the rate of API uptake from the solid form (e.g. from a tablet), ultimately influencing both its formulation chemistry and the pharmacokinetics of the API.

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Application note
Expanding High Throughput Nanolitre Solution-Phase Crystallisation for Polymorph Screening

Polymorphism is a solid-state phenomenon where a chemical species may adopt different conformational or packing arrangements, therefore allowing for the formation of more than one distinct crystal structure. Crystal polymorphs can exhibit varying physical and chemicalproperties. These properties such as solubility, hardness, colour, and melting point can all be important in the design of a compound in the crystal engineering and pharmaceutical industries. Typically, conducting polymorph screens requires a combination of classical crystallisation techniques which demand both large quantities of material and time to complete. Herein, we describe how encapsulated nanodroplet crystallisation (ENaCt) can be applied for low-quantity rapid polymorph screening using highly polymorphic 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY) and nicotinamide as test compounds. ENaCt polymorph screening resulted in the growth, and analysis, of single crystals of a new polymorph of ROY ‘O22’. Crystal forms of both ROY and nicotinamide previously thought to be inaccessible to solution-phase crystallisation were also successfully grown, highlighting the capabilities of ENaCt for screening a diverse polymorphic landscape.

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Poster
Design of Experiments for Discovery

As a methodology, DOE (design of experiments) used to be out of reach for many but is now far more accessible and scalable. With the right combination of software and hardware, a lot of the hard work is already done for you.

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Webinar
The Future of Automated Pipetting

In this live event, our panel of experts walked through the challenges that labs face with their liquid handling processes.

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Video
Intuitive By Design: SPT Labtech's mosquito® Software

The liquid handling software that controls SPT Labtech's mosquito family of positive displacement pipetting instruments gives users an intuitive experience tailored to their application area. Developed in collaboration with scientists, the latest mosquito software facilitates miniaturization in novel application areas. Packed with powerful features, the software includes an experiment designer and helpful wizards to create and manage your protocols.

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Video
Design of Experiments for Discovery

As a methodology, DOE (design of experiments) used to be out of reach for many but is now far more accessible and scalable. With the right combination of software and hardware, a lot of the hard work is already done for you. In this webinar, we teamed up with Synthace to bring you the lowdown on this fascinating topic.

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Webinar
A new era for automated liquid handling

In this two-part webinar, our Product Manager introduces the new apricot DC1 and provides practical guidance on making the switch from manual to automated pipetting.

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Webinar
apricot DC1 instrument overview

Anne Hammerstein introduces apricot DC1 and highlights some of the key features and applications of the instrument.

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Video
Integrated volume verification: Providing a safety net for your liquid handling workflows

Watch this webinar to learn how to improve your liquid handling quality control processes with automated volume detection.

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Webinar
Utilizing dragonfly to industrialize determination of irreversible inhibition kinetics and streamlining assay development

This three-part tutorial showcases how the dragonfly discovery is used in drug discovery at GlaxoSmithKline.

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Tutorial
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