Resources

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Drug Discovery

Webinar: Ultra-high throughput experimentation in medicinal chemistry

Join Tim Cernak, Associate Professor at the University of Michigan, and Kamila Koprowska, mosquito® Product Manager at SPT Labtech, as they explore how positive displacement technology and low-volume liquid handling drive scale and throughput in medicinal chemistry.

Webinar

Optimizing multi-cellular models for high-throughput screening - Webinar

Join us as we dive into recent research which has combined Design of Experiments methodology with automated liquid handling to develop a cardiotoxicity assay platform. We discuss how this approach could become routine in the future, not only offering more accurate predictability of new drug candidates, but also enabling researchers to leverage resources more efficiently through streamlined workflows and data-driven decision-making.

Webinar

Accelerating Drug Discovery at Totus Medicines: DNA-Encoded Library Screening with firefly®

DNA-encoded libraries (DELs) have emerged as a transformative technology within drug discovery. The exploration of large libraries of small molecule ligands as a collective rather than an individual has springboarded DELs to the forefront of high throughput screening. Building upon traditional DEL methods, Totus Medicines has developed a platform capable of identifying covalent small molecule ligands via high-throughput cell-based DEL screening. This poster outlines how Totus Medicines is streamlining hit identification, optimization, and technology development, to accelerate the discovery of novel therapeutic candidates using SPT Labtech’s firefly automated liquid handling platform. We present the metrics that have been collected over one year of screening using Totus Medicine’s proprietary covalent DELs to run over 2000 unique selections against a large number of targets, spanning diverse therapeutic areas.

Poster

High-throughput nanoscale crystallization for small organic molecules and pharmaceuticals

In this webinar, the methodologies employed in the ENaCt technique will be discussed with case studies highlighting the structural diversity of the method’s applicability, along with the mechanisms for easy access to the technique.

Webinar

How to accelerate small molecule lead discovery with automated multichannel pipetting and DEL technology

Establishing an efficient and accurate compound testing workflow is essential to any small molecule screening platform. When utilizing screening methods such as DNA-encoded library (DEL) technology, follow-up hit validation must be performed using traditional biochemical assays. In this webinar, we will review the use of mosquito LV to accelerate early-stage small molecule lead discovery through the lens of Hydroxyacid oxidase 1 (HAO1). In this case study, we will describe our efforts to develop and deploy a robust enzymatic assay towards the development of potent inhibitors identified by DEL technology for disease treatment.

Webinar

Streamline your liquid handling with scalable, integrated automation - Webinar Recording

Bringing together individual processes into an orchestrated workflow allows you to take a step further. It not only maximizes walk-away time but also fortifies your laboratory with flexible and scalable integrated workflows, ensuring seamless, end-to-end automation that aligns with the diverse needs of both budding biotech startups and established enterprise-level pharmaceutical organizations. In this webinar, experts from SPT Labtech and Biosero will share their specialist knowledge, first exploring the business benefits of combining these powerful technologies. We’ll then take a deeper dive into the practical considerations of implementing integration, sharing insights to give you the highest chance of success.

Webinar

mosquito® LV: An Assay’s Best Friend

After a successful DNA-encoded library (DEL) screen, it is essential to have access to a high-throughput method of assaying compounds to validate hits. The ability to create up to sixteen serial dilutions in parallel and subsequently plate those dilutions on a nanoscale can vastly speed up the hit finding process, while improving the accuracy and efficiency of the screen. mosquito® LV by SPT Labtech has greatly improved the way we work with our off-DNA compounds synthesized from DELcore and DELflex collaborations.

Application note

The Future Is Here: Precision Automation Demonstrates Its Value as a Tool for Accelerating Drug Discovery

With more than 70 FDA-approved small molecules ,kinase inhibition continues to attract significant investment. Identification and characterization of novel inhibitors is a challenging, yet critical task which sets the tone for future successes and failures. Traditional single shot approaches do not meet current requirements for machine learning and carry significant risks of false negatives. Hit profiling has evolved this concept, generating potency estimates, reducing risks while providing contextual confidence. Accurate hit identification followed by high resolution, kinetic molecular profiling enhances outcomes ensuring better data-driven decision-making earlier in the process, saving time and resources, leading to superior molecular design.

Poster

SLAS 2023 Interview - Chris Waddling - dynamic duo

Discover how genomics researchers can miniaturize NGS methods to increase throughput and lower costs using the combination of the mosquito® and dragonfly® automated liquid handlers from SPT Labtech in this interview with Field Application Scientist, Chris Waddling.

Video

encapsulated nanodroplet crystallisation (ENaCt) for small organic molecules: polymorph discovery

Crystallisation is of vital importance to the drug development pipeline of the pharmaceutical industry due to the existence of multiple crystal forms (e.g. cocrystals, solvates and polymorphs) of an active pharmaceutical ingredient (API). The physical properties of the crystal form of an API are important in manufacturing, API stability and can have significant impact on the rate of API uptake from the solid form (e.g. from a tablet), ultimately influencing both its formulation chemistry and the pharmacokinetics of the API.

Application note

Expanding High Throughput Nanolitre Solution-Phase Crystallisation for Polymorph Screening

Polymorphism is a solid-state phenomenon where a chemical species may adopt different conformational or packing arrangements, therefore allowing for the formation of more than one distinct crystal structure. Crystal polymorphs can exhibit varying physical and chemicalproperties. These properties such as solubility, hardness, colour, and melting point can all be important in the design of a compound in the crystal engineering and pharmaceutical industries. Typically, conducting polymorph screens requires a combination of classical crystallisation techniques which demand both large quantities of material and time to complete. Herein, we describe how encapsulated nanodroplet crystallisation (ENaCt) can be applied for low-quantity rapid polymorph screening using highly polymorphic 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY) and nicotinamide as test compounds. ENaCt polymorph screening resulted in the growth, and analysis, of single crystals of a new polymorph of ROY ‘O22’. Crystal forms of both ROY and nicotinamide previously thought to be inaccessible to solution-phase crystallisation were also successfully grown, highlighting the capabilities of ENaCt for screening a diverse polymorphic landscape.

Poster

The Future of Automated Pipetting

In this live event, our panel of experts walked through the challenges that labs face with their liquid handling processes.

Video

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