High-throughput nanoscale crystallization for small organic molecules and pharmaceuticals

In this webinar, the methodologies employed in the ENaCt technique will be discussed with case studies highlighting the structural diversity of the method’s applicability, along with the mechanisms for easy access to the technique.

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About the webinar

The explosion of technologies, enabling the application of diffraction science to ever more complex materials, is truly staggering. With microfocus in-house X-ray sources through to the international XFEL facilities now being used to help resolve structural properties and molecular characteristics. However, all of these and their related instruments still have a common requirement, the prior preparation of a suitably crystalline sample for analysis. 

Increasingly exotic molecular systems are now being prepared synthetically, or isolated from natural sources, as targets of interest. These targets suffer greatly from difficulties in structure elucidation outside the solid-state due to the complexities of data and information loss from spectroscopic methods. Therefore, the reliance on solid-state methods has increased for categoric materials characterisation. However, these increasingly complex molecular species have associated complications in determining suitable crystallisation conditions to provide samples of suitable quality for analysis. 

Additionally, as both academia and industry strive to reduce the timescales for research projects bringing solid-state analysis earlier in the development pipeline is imperative. It has the advantage of reducing costs on projects that are less likely to come to fruition but has the major disadvantage that the quantity of material available is generally significantly reduced. The reduction in sample quantity available for analysis makes many classical crystallisation routes non-viable or extremely cost inefficient due to the sample recycling and additional processing required. 

High throughput Encapsulated Nanodroplet Crystallisation is a recently developed technique that has the capability to provide solutions to the problems outline. It has been successfully employed on a diverse range of structurally challenging compounds from small molecules through inorganic complexes to natural products and their synthetic analogues. The method has the major advantages of the limited amount of material required for crystallisation screening (<10 mg material gives >1000 crystallisations) and ease of polymorph screening across a wide range of chemical environments.

About the presenter 

Michael obtained his MChem from the University of Oxford in 2001 and completed his PhD at Durham University in 2005. As a PDRA and Senior Research Fellow at Durham University, he developed SCXRD equipment and computational tools for the study of crystals under extreme conditions. He joined Newcastle University in 2013 and in 2020 launched Indicatrix Crystallography Ltd with Dr Michael Hall. In 2022, he became the lead for the Newcastle University section of the NCS focusing on high-throughput crystallization. 

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