Establishing an efficient and accurate compound testing workflow is essential to any small molecule screening platform. When utilizing screening methods such as DNA-encoded library (DEL) technology, follow-up hit validation must be performed using traditional biochemical assays.
In this webinar, we will review the use of mosquito LV to accelerate early-stage small molecule lead discovery through the lens of Hydroxyacid oxidase 1 (HAO1). In this case study, we will describe our efforts to develop and deploy a robust enzymatic assay towards the development of potent inhibitors identified by DEL technology for disease treatment.
Key learning objectives:
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