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Optimize cryo-EM sample preparation workflows

chameleon delivers optimized grid vitrification for cryo-EM by combining next-generation automation, blotless grid technology, and high speed plunging. Thinking beyond existing sample preparation workflows enables routine high resolution structural studies.

Onboard cameras provide visual images during freezing
Onboard cameras provide visual images during freezing

Enabling the easier selection of only good grids based on visual images during freezing reduces the requirement for costly microscope screening and saves valuable research time.

High-speed plunging
High-speed plunging

chameleon’s high speed plunging capability reduces air-water interface protein denaturation effects and allows better handling of difficult samples to improve quality and enable better research outcomes.

Blot-free technology
Blot-free technology

The blot-free technology using self wicking grids minimizes variability and enables researchers to gain precise sample specific control of ice thickness.

 Precise automated grid handling
Precise automated grid handling

With almost no manual handling required, chameleon eliminates common grid damage and loss issues to increase workflow efficiency and reduce waste.

Guided workflows enable simple set up, use and cleaning
Guided workflows enable simple set up, use and cleaning

Intuitive design makes the instrument easy to use even for novice operators, minimizing training time and streamlining set up.

In-line glow discharge
In-line glow discharge

Easily apply real time adjustments to perfect your sample behaviour and achieve the perfect ice thickness.

Automated cryogen level sensing and temperature control
Automated cryogen level sensing and temperature control

Ensure the safe storage and control of cryogens in an automated drawer to maintain their stability and quality and assure research integrity.

Captures all relevant grid parameters and images
Captures all relevant grid parameters and images

Improved data collection and record keeping enables future repeatability as well as data mining to inform new research avenues.

Technical Specification

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Minimum sample volume 5 µL Sample block temperature control 4°C to 37°C
Minimum dispense volume 6 nL Weight 300kg
Standard dispense-to-plunge time 101 msec Dimensions (W x D x H) 916 mm x 708 mm x 1687 mm
Fastest dispense-to-plunge time 54 msec

What our customers
say about chameleon

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“Through an HHMI emerging technology opportunity, we were able to engage with SPT Labtech in the development of chameleon, from a prototype to the latest commercial model. During the project, we encountered many examples where chameleon improved macromolecular integrity, ice quality, and specimen reproducibility. With better grids comes more efficient microscope usage, fewer consumables, and improved reconstructions. In addition, we experienced exceptional technical support and service, keeping our instrument running optimally. We are thrilled to continue exploring the benefits of this next-generation specimen preparation technology”

Researcher

MIT

    We make instruments that change the way scientists work.

    As a team of exceptionally skilled scientists, engineers and business innovators, we have one mission: to work together to accelerate life science research.

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