Resources

Explore insightful resources that include videos, whitepapers, eBooks, application notes and more

An introduction to mosquito Gen3 - Product Overview

Introducing our most compact and accessible member of the mosquito family. mosquito Gen3 offers highly accurate and precise multi-channel pipetting from 500 nL to 5 µL, allowing genomics researchers to benefit from miniaturization across a range of applications, irrespective of liquid class. The instrument’s rapid plate-to-plate pipetting motion and tip exchange maximize speed and efficiency.

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Video
Miniaturized Illumina Nextera XT library preparation on mosquito® to support high-throughput sequencing services

This application note highlights how mosquito HV genomics has been used to automate the Illumina Nextera XT protocol at SEQ-IT, achieving 5X miniaturized reaction volumes while delivering reproducible, high-quality libraries. Based in Kaiserslautern in Germany, SEQ-IT is a mid-sized company offering both Sanger sequencing and NGS services.

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Application note
Achieving cost-effective NGS through automated miniaturization of Illumina Nextera XT library preparation

This poster highlights how mosquito HV genomics has been used to automate the Illumina Nextera XT protocol at SEQ-IT, achieving 5X miniaturized reaction volumes while delivering reproducible, high-quality libraries. This miniaturized method was developed to identify and screen mutations with oncogenic potential and drug resistance (HIV, HBV, HCV), SNP detection, as well as in HLA-typing, among other applications.

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Poster
Developing and Embedding In-House Compound Management within Artios

Using dedicated software and automation, Artios have developed in-house compound management for Design-Make-Test-Analyze processing and assay-ready plate generation. This results in: - Increased sample and data integrity through audited and trackable processes - Reduced cycle times and cost - Faster data reporting for better decision making and use of resources

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Poster
Advancing in vitro high-throughput transcriptomics for chemical toxicity testing | SPT Labtech

Hear from researchers from McGill University, as they present case studies in optimizing and advancing efficient workflows that couple in vitro exposures with ultraplexed library preparation using the QIAseq UPXome RNA Library Kit. This approach has increased the throughput of differential expression and dose-response analysis for tPODs derivation.

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Webinar
Webinar: Ultra-high throughput experimentation in medicinal chemistry

Join Tim Cernak, Associate Professor at the University of Michigan, and Kamila Koprowska, mosquito® Product Manager at SPT Labtech, as they explore how positive displacement technology and low-volume liquid handling drive scale and throughput in medicinal chemistry.

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Webinar
Developing and Embedding In-House Compound Management within Artios

Design, Make, Test and Analyse (DMTA) screening requires the generation of compound assay ready plates (ARP) – a process that can be slow, costly and resource intensive. Negative impact on project cycle times/resource burden. Using dedicated software and automation, we have developed in-house compound management (CM) for DMTA processing and plate generation: Audited and trackable process – increased sample/data integrity. Fully automated workflow for biochemical & cellular assays. Reduced cycle times/cost. Faster data reporting to drive decision making/more effective use of resources.

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Poster
BraMosA: Our New Smartcel-2 boosting Serial Dilution Preparation

Enhancing throughput while reducing footprint is a recurring requirement in sample management. With the new Smartcel-2 from Flexible Lab Solutions, we have significantly boosted our capability to prepare assay-ready plates in a serial dilution format. This double-deck automation system features a Bravo from Agilent for high-volume serial dilution plate preparation and a mosquito LV from SPT Labtech for nanoliter dispensing steps. Several peripheral devices, including a peeler, sealer, centrifuge, and plate storage, enable the automation cell to operate around the clock.

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Poster
Scaling up plate-based single-cell profiling: introducing automated STORM-seq

Full-length, single-cell RNA-seq (scRNA-seq) allows for more complete transcriptomic profiling compared to 5' or 3' end-counting methods. However, labor-intensive, non-modular workflows with high reagent costs limit scalability. Advancements in laboratory automation, protocol design, and reaction miniaturization have overcome some of these constraints. In collaboration with the Van Andel Institute, we present Single-cell TOtal RNA Miniaturized sequencing (STORM-seq), which pairs Takara Bio’s SMART® technology with SPT Labtech’s mosquito® HV genomics liquid handling platform. This miniaturized, plate-based scRNA-seq approach is scalable, automated, and offers a solution for single-cell transcriptomic profiling (i.e., coding/noncoding transcripts, isoforms, gene fusions, etc.) at reduced cost and increased cell throughput.

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Poster
Towards high-throughput low-cost sustainable ecotoxicity testing

Traditional whole animal-based toxicity testing is expensive, time-consuming, and unethical. Furthermore, these tests do not capture the full range of biological impacts. There is growing interest in developing alternative methods (New Approach Methods, NAMs), that are less resource intensive (lower costs, quicker assays, fewer animals), while also providing more data on the mechanism of toxicity. The objective of this work was to optimize and establish a high throughput in vitro transcriptomic-based toxicity testing platform for chemical and environmental risk assessment. The platform couples human Caco-2 and Hep G2 cell lines with QIAGEN’s UPXome ultraplex technology, so that the combined test system can also derive transcriptomic points of departure (tPODs).

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Poster
Miniaturization of DNA library preparation for Illumina sequencing using automated positive displacement liquid handling

Advances in next generation sequencing have resulted in huge increases in throughput with associated decreases in costs. As a result, the process of library preparation has become even more of a financial and time constraint to high throughput sequencing core facilities. Automation, in the form of liquid handling robots, has been able to alleviate some of these bottlenecks. This work describes the application of SPT Labtech’s mosquito® HV positive displacement nanoliter liquid handler to successfully implement the preparation of DNA libraries for Illumina sequencing at one tenth the volume of the original manual protocol.

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Poster
How to accelerate small molecule lead discovery with automated multichannel pipetting and DEL technology

Establishing an efficient and accurate compound testing workflow is essential to any small molecule screening platform. When utilizing screening methods such as DNA-encoded library (DEL) technology, follow-up hit validation must be performed using traditional biochemical assays. In this webinar, we will review the use of mosquito LV to accelerate early-stage small molecule lead discovery through the lens of Hydroxyacid oxidase 1 (HAO1). In this case study, we will describe our efforts to develop and deploy a robust enzymatic assay towards the development of potent inhibitors identified by DEL technology for disease treatment.

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Webinar
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