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Resources (448)

mosquito LV

Glaiser, V. (2011) Dispensing with manual pipetting. GEN. 31 (12)

Screening, Low volume liquid handling

Bulfer, S. L. et al. (2011) Application of a high-throughput fluorescent acetyltransferase assay to identify inhibitors of homocitrate synthase. Anal Biochem

Sitting drop crystallization

Chang, A. et al. (2011) Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.Proc Natl Acad Sci USA. 108: 17649-54

Sitting drop crystallization

Koldobskaya, Y. et al. (2011) A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nat Struct Mol Biol. 18(1):100-6

Lipidic Cubic Phase (in-meso)

Gaisford, W. et al. (2011) mosquito LCP: making membrane protein crystallisalization accessible to the research scientist; Nature Methods 8. Appl. Note.

Sitting drop crystallization

Mueller, I. et al. (2011) Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation; Bioorg Med Chem Lett. 21(18):5244-7

Hanging drop crystallization

Chaptal, V. et al. (2011) Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition. Proc Natl Acad Sci USA. 108: 9361-6

Hanging drop crystallization, Sitting drop crystallization

Gaisford, W. (2011) The Rapid Screening and Optimisation of Crystallisation Conditions of the Bacterial Periplasmic Binding Protein, HbpA and the Elucidation of its Role as a Glutathione Import Protein; Technology Networks: Crystallography,

Sitting drop crystallization

Mueller, I. et al. (2011) A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme; J Mol Biol. 410(2):307-15

Cell-based assay screening

Wang et al. 2010. Assessment of the susceptibility of mutant HIV-1 to antiviral agents. J. Virological Methods 165:230-237

Cell-based assays, Cell-based assay screening

Shukla, et al., The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform. Drug Discov Today. 2010 Dec;15(23-24):997-1007

Cell-based assays

Phong et al. 2010. The p38 MAPK promotes cell survival in response to DNA damage but is not required for G2 DNA damage checkpoint in human cancer cells. Mol Cell Biol. 30(15):3816-26

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