Sitting drop crystallization
Lisa, M., et al. (2019). Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor. Nucleic acids research
High throughput transcriptomics
Rodriguez-M., et al. (2019). Unravelling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA sequencing. Molecular cell
Screening
Heap, R., et al. (2019). Profiling embryonic stem cell differentiation by MALDI-MS: development of a reproducible and robust sample preparation workflow. bioRxiv
Screening
Reinke, A., et al. (2019). Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate. Journal of Biological Chemistry
Screening
Winter, M., et al. (2019). Automated MALDI Target Preparation Concept: Providing Ultra-High-Throughput Mass Spectrometry–Based Screening for Drug Discovery. SLAS TECHNOLOGY: Translating Life Sciences Innovation
Screening
Schaaf, T., et al. (2018). Red-Shifted FRET Biosensors for High-Throughput Fluorescence Lifetime Screening. Biosensors
Screening
Winter, M., et al. (2018). Establishing MALDI-TOF as versatile drug discovery readout to dissect the PTP1B enzymatic reaction. SLAS DISCOVERY: Advancing Life Sciences R&D
Screening
Lo, C., et al. (2018). A novel small molecule screening platform for disrupting toxic tau oligomers in cells. bioRxiv
Cell-based assays
Wang, J., et al. (2019). Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nature medicine
Cell-based assays
Klanert, G., et al. (2019).. A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets. Scientific Reports
Cell-based assays
Lesch, M., et al. (2019). RNAi-based small molecule repositioning reveals clinically approved urea-based kinase inhibitors as broadly active antivirals. PLoS pathogens
Cell-based assays
Harris, I., et al. (2019).Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell metabolism