Tyler, A. R., et al. (2020). Encapsulated Nanodroplet Crystallization of Organic-Soluble Small Molecules

mosquito crystal

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Enabling this work to develop a novel high-throughput method for single-crystal x-ray diffraction on mosquito® with Dr Michael J. Hall (Newcastle Uni) and his teams have been a pleasure for us at SPT Labtech. Having the ability to quickly screen organically soluble small molecules on the microgram scale will no doubt deliver valuable insight for both academic research and pharmaceutical drug design and validation.

Their novel Encapsulated Nanodroplet Crystallisation (ENaCt) method:

  • minimises the amount of valuable synthetic product required for characterisation by single crystal x-ray diffraction

  • displays the ability to solve previously uncrystallisable structures – evidenced in the paper by the fungicide dithianon

  • provides the ability to screen for previously unseen polymorphs.

This short 3-minute video, kindly provided by Dr Michael J. Hall, demonstrates the ENaCt Crystallisation Procedure in practice. 

To learn more, download the accompanying publication which showcases this methodology through the crystallization of a diverse set of small molecules, including “uncrystallizables,” combined with structural analysis by X-ray diffraction.

For more information about mosquito crystal, the high-throughput liquid-handling robot used in this study, click here.